Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool
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چکیده
منابع مشابه
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.
In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with (2)H(2)O in human adults revealed a low daily pr...
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*Department of Immunology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands; †Department of Clinical Viro-Immunology, Sanquin Research Center, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1000 GG, Amsterdam, The Netherlands; Departments of ‡Clinical Chemistry and §Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam,...
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What are the rules that govern a naive T cell's prospects for survival or division after export from the thymus into the periphery? To help address these questions, we combine data from existing studies with robust mathematical models to estimate the absolute contributions of thymopoiesis, peripheral division, and loss or differentiation to the human naive CD4+ T-cell pool between the ages of 0...
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To examine directly whether a limited number of naive T cells transferred to lymphopenic hosts can truly fill the peripheral naive T cell pool, we compared the expansion and phenotype of naive T cells transferred to three different hosts, namely recombination-activating gene-deficient mice, CD3epsilon-deficient mice, and irradiated normal mice. In all three recipients, the absolute number of re...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0709713105